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Berberine Balance supplies berberine combined with alpha lipoic acid and grape seed extract for healthy blood sugar and cardiovascular support. Recent studies indicate that berberine, a naturally occurring alkaloid found in a number of plants, is an effective supplement for helping to maintain cardiometabolic health. Grape seed extract is a well-known antioxidant with heart health benefits, and alpha lipoic acid helps to support proper insulin function.


Supplement Facts

  • Amount Per Serving
  • Serving Size 1 Vegetarian Capsule • Servings Per Container 60
  • Berberine HCI (from Berberis aristata extract, root)500 mg
  • Alpha Lipoic Acid50 mg
  • Grape Seed Extract50 mg
  • Other ingredients: Hydroxypropyl methylcellulose (capsule), hydroxypropyl cellulose, vegetable stearate, and silica
  • Suggested Usage: 1, twice daily


PRODUCT DATA DOUGLAS LABORATORIES® 05/2015 DESCRIPTION Berberine Balance supplies high potency berberine combined with alpha lipoic acid and grape seed extract for already healthy blood sugar and cardiovascular support. Grape seed extract is a well-known antioxidant with heart health benefits, and alpha lipoic acid helps to support proper insulin function. † FUNCTIONS Berberine is a naturally occurring alkaloid and a primary constituent of several plants including barberry, goldenseal, and phellodendron. Recent studies indicate that berberine is a helpful supplement for maintaining cardiometabolic health. † Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. † In vivo and in vitro experiments have also shown blood pressure support and vasorelaxatory effects of berberine. † The vascular sites for this activity of berberine are not completely clear. It seems that berberine acts on both the endothelium and the underlying vascular smooth muscle to induce vasorelaxation via multiple cellular mechanisms. Berberine’s history of usage in Ayurvedic and Chinese medicine dating back approximately 3,000 years has shown to help maintain a healthy microbial balance. † Polyphenols, part of a broad class of bioflavonoids, are commonly found in grape seeds. One type, known as proanthocyanidins is highly regarded for their strong antioxidant properties, and for their functions in supporting the capillaries. † Proanthocyanidins appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved in physiological processes. † Alpha lipoic acid is a nutritional coenzyme that is involved in the energy metabolism of proteins, carbohydrates and fats, has physiological functions in blood glucose clearance, and is able to scavenge a number of free radicals. † This important coenzyme appears to be necessary for the normal transport of blood glucose into the cell. In addition, alpha lipoic acid has been shown to support AMP-activated protein kinase (AMPK), a major regulator of cellular energy metabolism. † FORMULA (#201131) Each vegetarian capsule contains: Berberine HCl.......................................................................... 500 mg (from Berberis aristata extract, root) Alpha lipoic acid ...................................................................... 50 mg Grape Seed extract ................................................................. 50 mg Other ingredients: Cellulose, dicalcium phosphate, vegetable stearate and silica. INDICATIONS Berberine Balance is a useful dietary supplement for those individuals who wish to support blood glucose metabolism and/or cholesterol maintenance. SUGGESTED USE Adults take 1 capsule twice daily or as directed by your health care professional. SIDE EFFECTS May cause gastrointestinal adverse effects in some individuals. Berberine may increase bilirubin levels. Berberine displaces bilirubin from albumin and increases total and unbound bilirubin concentrations. DRUG INTERACTIONS: Berberine appears to undergo phase I hepatic metabolism. There is preliminary evidence that berberine might inhibit cytochrome P450 3A4, 2C9, 2D6 enzymes. Therefore, watch for an Berberine Balance 2 PRODUCT DATA DOUGLAS LABORATORIES® 05/2015 increase in the levels of drugs metabolized by these enzymes in patients taking berberine. WARNING: DO NOT TAKE IF PREGNANT OR LACTATING STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children. REFERENCES Yifei Zhang, et al. J. Clin. Endocrinol. Metab. published online Apr 8, 2008;doi: 10.1210/jc.2007-2404. [Berberine]. Jun Yina, Huili Xing, and Jianping Yeb. Metabolism. 2008 May ; 57(5): 712–717. [Berberine]. GUO Yi. Chinese Medical Journal 2008; 121(13):1197-1203. [Berberine]. Kong W, et al. Nat Med. 2004 Dec;10(12):1344-51. [Berberine]. Zeng XH, Zeng XJ, Li YY. Am J Cardiol 2003;92:173-6. [Berberine]. Wojtyczka RD, et al. Molecules. 2014 May 22;19(5):6583-96. doi: 10.3390/molecules19056583. [Berberine]. Fan H, Chen YY, Bei WJ, Wang LY, Chen BT, Guo J. Evid Based Complement Alternat Med. 2013;2013:459390. doi: 10.1155/2013/459390. [Berberine]. Chan E. Biol Neonate 1993;63:201-8. [Berberine]. Lee WJ,et al. Biochem Biophys Res Commun. 2005 Jul 8;332(3):885-91. [Alpha-lipoic acid]. Ibrahimpasic K. Med Arch. 2013;67(1):7-9. [Alpha-lipoic acid]. Kamenova P. Hormones (Athens). 2006 Oct-Dec;5(4):251-8. [Alpha-lipoic acid]. Bagchi D, Bagchi M, Stohs SJ, et al. Ann N Y Acad Sci 2002;957:260-70. [Proanthocyanidins]. Pataki T, et al. Am J Clin Nutr. 2002 May;75(5):894-9. [Proanthocyanidins]. For more information on Berberine Balance, visit † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Berberine Balance

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